That being said, the puppies could be conceived by natural mating. (Even a first generation could be conceived by NM with a box for the male to stand on, but I've heard AI has better litter sizes.) What the Cavador was bred with would be the question. Cavador to Cavador no problems, but they may not look like the parent dogs. Cavador to Cavalier would be fine if the mother was the Cavador. If the mother would was the Cavalier it would likely be ok, but its not ideal. Cavador to Labrador would be fine if the mother was the Labrador, but again I would be a little hesitant if the mother was the Cavador.