I just think we're starting to paying some pretty heavy prices for chasing purity and perfection. I think you can achieve specialisation without resorting to inbreeding practices and achieve a compromise between excelling at particular tasks and retaining some genetic diversity.
You see it in all examples where inbreeding has been adopted. Just the other day a family friend was complaining about bananas. He said these ones (Cavendish) taste like crap. He mentioned that there had been a banana species previously that had been much tastier. Well, given that bananas are my favourite herb/berry/fruit thing I was intrigued. We lost almost all of the previous species, the Gros Michel to the Panama fungus. Well now the fungus is back and unfortunately, although the Cavendish (the current species) were resistant to the first strain, they don't believe they will be resistant to this 2nd strain. And of course, all Cavendish bananas are genetically identical, we bred a 'superior' product which can not reproduce or survive on its own but that met all of our criteria. And now there's a chance we'll have to start again, with a new species.
I'm not saying that you don't have the potential to get exciting and/or good results from inbreeding. But this article does a good job of articulating the cost of such practices and I just think there needs to be more consideration of that. It could be done perfectly if we had a perfect understanding and perfect control over the dog genome and the way genes mutate and interact with each other but we don't and when we remove all of the natural safeguards in place through sexual reproduction (rather than asexual) through inbreeding practices, well I think there's a definite case for considering whether the benefits are always worth it. And honestly, having met a lot of breeders (particularly within some breeds), I don't believe they're always the best people for the job. I am really excited at the prospect of people from different backgrounds (not just people who want to show dogs) and particularly those with more in-depth knowledge around science, wanting to get involved in breeding better dogs.